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Emerson Krock

Title: 
Assistant Professor
Emerson Krock
Contact Information
Email address: 
emerson.krock [at] mcgill.ca
Biography: 

Dr. Krock鈥檚 research program focuses on painful autoimmune diseases and the regulation sensory neuron plasticity through satellite glia cells and extracellular matrix remodeling within the dorsal root ganglia. He is also specifically interested in the development of painful autoantibodies through molecular mimicry with the microbiome. His research uses a combination of animal models, human samples, and human clinical data and leverages techniques like animal behavior, tissue-clearing immunofluorescent staining, machine vision-aided image analysis, cell culture and flow cytometry.

Dr. Krock completed his PhD at 91社区 with Drs. Lisbet Haglund and Jean Ouellet, investigating the cellular mechanisms of intervertebral disc degeneration that lead to pain. He then did his postdoc training at the Karolinska Institute in Stockholm, Sweden with Dr. Camilla Svensson where his research focused on pain-inducing autoantibodies in rheumatoid arthritis and fibromyalgia.

Degree(s): 

PhD, 91社区

BA and BSc, 91社区

Areas of expertise: 
  • Autoantibodies and pain
  • Pain neuroimmunolgy
  • Satellite glia cells
  • Extracellular matrix remodeling
  • Arthritis and pain
Office: 
Duff Medical Building, 204
Research areas: 
Pain and Neuroscience
Awards, honours, and fellowships: 
  • CIHR Postdoctoral Fellowship
  • International Association for the Study of Pain John J. Bonica Postdoctoral Fellowship
  • Fonds de Recherche Sant茅 Quebec Doctoral Fellowship
Selected publications: 

E. Krock, C.E. Morado-Urbina, J. Menezes, M.A. Hunt, A. Sandstr枚m, D. Kadetoff, J. Tour, V. Verma, K. Kultima, L. Haglund, C.B. Meloto, L. Diatchenko, E. Kosek, C.I. Svensson; Fibromyalgia patients with high levels of anti-satellite glia cell IgG antibodies present with more severe symptoms; PAIN, accepted, in press

Z. Kurtovic, C.I. Svensson, K. Krock; Bugs improve nerve regeneration: fasting-induced, microbiome-derived metabolite enhances peripheral nerve regeneration; Signal Transduction and Targeted Therapy; 2022 Oct 5;7(1):351.

J. Su*, E. Krock*, S Barde, A Denaley, J Kato, N Agalave, G Wigerblad, R Matteo, Roger Sabbadini, Anna Josephson, Kim Kultima, T H枚kfelt, CI Svensson; Pain-like behaviour in collagen antibody-induced arthritis is regulated by lysophosphatidic acid and activation of satellite glia cells;, Brain, Behavior and Immunology, 2022 Mar;101:214-230 *denotes co-first authorship

A. Goebel*, E. Krock*, C. Gentry, U. Cuhadar, M.R. Isreal, A. Jurczak, C. Morado Urbina, K. Sandor, N. Vastani, S. Sensi, Y. Nomura, J. Menezes, A. Baharpoor, L. Brieskorn, A. Sandstrom, J. Tour, D. Kadetoff, L. Haglund, E. Kosek, S. Bevan, C.I. Svensson, D.A. Andersson; Passive transfer of fibromyalgia from patients to mice; The Journal of Clinical Investigation; 2021 Jul 1;131(13):144201 *denotes co-first authorship

E. Krock, M. Millecamps, K.M. Anderson, A. Srivastava, T.E. Reihsen, P. Hari, Y.R. Sun, S.H. Jang, G.L. Wilcox, K.G. Belani, D.S. Beebe, J. Ouellet, M.R. Pinto, L.J. Kehl, L. Haglund, L.S. Stone; Interleukin-8 as a therapeutic target for chronic low back pain: Upregulation in human cerebrospinal fluid and pre-clinical validation with chronic reparixin in the SPARC-null mouse model; EBioMedicine, 2019; May;43:487-500.

E. Krock, J.B. Currie, M.H. Weber, J.A. Ouellet, L.S. Stone, D.H. Rosenzweig, L. Haglund; Nerve Growth Factor is Regulated by Toll-Like Receptor 2 in Human Intervertebral Discs; Journal of Biological Chemistry, 2016; VOL. 291, NO. 7, pp. 3541鈥�3551

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