Dr. Benoit Gentil
Title:
Assistant Professor
Academic title(s):
Director, 91社区 Laboratory of Genetics and Epigenetics in Motor Development
Division:
Biomechanics and Neuroscience Supervisors
Department:
Kinesiology & Physical Education
Area(s):
Biomechanics, Neuroscience and Physiology
Sports and Exercise Sciences
Areas of expertise:
- Biomechanics and neuroscience
- Motor development
- Rare neurological disease
- Genetics and epigenetics
- Neurobiology; stress and stress proteins
Link(s):
Degree(s):
- Postdoctoral Fellow, Department of Biochemistry, 91社区, (Mentor: Walter Mushynski)
- Postdoctoral Fellow, Department听of Neurology and Neurosurgery, 91社区, (Mentor: Jean-Pierre Julien)
- Ph.D., Molecular and Cell Biology. Universit茅 Joseph Fourier, Grenoble
- M.Sc. in Human Nutrition, Dipl么me d鈥橢tudes Approfondies in Physiology and Pathology of Human Nutrition, University Diderot (Paris VII)
- Licence (BSc) in Biology and Physiology, University Joseph Fourier, Grenoble
Selected publications:
- Dagher R*, Massie R, Gentil BJ. MTP deficiency caused by HADHB mutations: Pathophysiology and clinical manifestations.Mol Genet Metab. 2021 May;133(1):1-7
- A. Dabbaghizadeh*, A. Par茅*, Z. Cheng-Boivin*, R. Dagher*, S. Minotti**, M.Dicaire, B. Brais, J. Young, H.D. Durham, B.J. Gentil. The J domain of sacsin disrupts intermediate filament assembly. Bio Rxiv 2021.
- D.L. Demy, M.L. Campanari, R. Munoz-Ruiz, H.D. Durham, B.J. Gentil, E. Kabashi, Functional Characterization of Neurofilament Light Splicing and Misbalance in Zebrafish, Cells, 9(2020).
- R. Kuta, N. Larochelle, M. Fernandez, A. Pal, S. Minotti, M. Tibshirani*, K. St Louis, B.J. Gentil, J.N. Nalbantoglu, A. Hermann, H.D. Durham, Depending on the stress, histone deacetylase inhibitors act as heatshock protein co-inducers in motor neuronsand potentiate arimoclomol, exerting neuroprotection throughmultiple mechanisms in ALS modelsCell Stress Chaperones 25 (2020) 173-191.
- J.Baudier, B.J. Gentil, The S100B Proteinand Partners in Adipocyte Responseto Cold Stressand Adaptive Thermogenesis: Facts, Hypotheses, and Perspectives. Biomolecules 10 (2020).
- B.J. Gentil, G.T. Lai *, M. Menade,R. Lariviere, S. Minotti**, K. Gehring, J.P. Chapple, B. Brais, H.D. Durham, Sacsin, mutated in the ataxia ARSACS, regulates intermediate filament assembly and dynamics FASEB J 33 (2019) 2982-2994.
- M. Tibshirani, B. Zhao, B.J. Gentil, S. Minotti, C. Marques, J. Keith, E. Rogaeva, L. Zinman, C. Rouaux, J. Robertson, H.D. Durham, Dysregulation of chromatin remodelling complexes in amyotrophic lateral sclerosis Hum Mol Genet 26 (2017) 4142-4152.
- B.J. Gentil, E. O'Ferrall, C. Chalk, L.F. Santana, H.D. Durham, R. Massie, A New Mutationin FIG4 Causes a SevereForm of CMT4J Involving TRPV4 in the Pathogenic CascadeJ Neuropathol Exp Neurol 76 (2017) 789-799.
- E.J. Duncan, R. Lariviere, T.Y. Bradshaw, F. Longo, N. Sgarioto, M.J. Hayes, L.E.L. Romano,S. Nethisinghe, P. Giunti, M.B. Bruntraeger, H.D. Durham, B. Brais, F. Maltecca, B.J. Gentil, J.P. Chapple,Altered organization of the intermediate filament cytoskeleton and relocalization of proteostasis modulators in cells lacking the ataxia protein sacsin Hum Mol Genet 26 (2017) 3130-3143.
听
Program:
- M.Sc.听Biomechanics and Neuroscience
- Ph.D. Kinesiology Sciences (Biomechanics and Neuroscience)
Graduate supervision:
Accepting Master's and Ph.D students for the 2024-25 academic year.
Students interested in pursuing training opportunities are encouraged to contact Dr. Gentil directly, providing a copy of their current r茅sum茅.
