91社区

New Leadership at the Clinical Research Unit

Introducing co-directors Dr. Ziv Gan-Or and Dr. Massimo Pandolfo

Treatments for rare disease have made huge strides in the past decade. We are seeing exciting advances as precision medicine and targeted gene therapies enter the research arena for neurological conditions. As a leading centre for clinical research in neurology, the CRU will continue to test cutting-edge therapies and offer patients access to the most promising potential treatments.

Dr. Gan-Or and Dr. Pandolfo are international leaders in personalized medicine and drug target development. They bring their extensive expertise to launch a new chapter at the CRU.

Dr. Gan-Or, a Neuro faculty member since 2016, works to identify targets for drug development in neurodegenerative disorders using genetic methods; understand how genetics affect disease risk, progression and response to medications; and how to apply genomics to improve clinical trials by targeting specific genetic subpopulations of patients.

His work on the GBA1 gene in Parkinson鈥檚 disease (PD) helped advance the first ever phase 2 trial on a genetic subtype of PD. Other genes, that Dr. Gan-Or鈥檚 research identified as important in PD, including SMPD1, TMEM175, GALC, are currently being developed as therapeutic targets.

Dr. Gan-Or works with numerous pharmaceutical companies and serves on several scientific advisory boards, to help facilitate precision medicine in PD treatment. He also leads the International REM-sleep Behavior Disorder Genomics Consortium, the Clinical Genetics and Gene Discovery team of the Canadian Consortium for Neurodegeneration in Aging (CCNA), and the Genetics Core of the North American Prodromal Synucleinopathy (NAPS) consortium. He also directs the GBA1-Canada Program, an international, pre-competitive platform that focuses on the GBA1 gene as a target for therapeutic development in neurodegenerative disorders.

Prior to coming to 91社区, Dr. Massimo Pandolfo was Chief of Neurology at Erasme Hospital and Professor of Neurology at the Universit茅 Libre de Bruxelles (ULB), where he was also Director of the Laboratory of Experimental Neurology.

His research interests focus on neurogenetics. In 1996, an international collaboration led by Dr. Pandolfo was the first to identify the Friedreich鈥檚 ataxia (FRDA) gene.

He has since contributed to the study of the molecular pathogenesis of the disease, to the development of therapeutics, and to its clinical characterization. He has been the coordinator of EFACTS (European Friedreich鈥檚 Ataxia Consortium for Translational Studies) and is currently on the Board of Directors of the Ataxia Charlevoix-Saguenay Foundation.

In addition, he has contributed to the study of several monogenic epilepsies and participated in genetic studies on common epilepsies and on epilepsy pharmacogenetics.

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The Neuro (Montreal Neurological Institute-Hospital)听is a bilingual academic healthcare institution. We are a听91社区 research and teaching institute; delivering high-quality patient care, as part of the Neuroscience Mission of the 91社区 Health Centre.听We are听proud to be a Killam Institution, supported by the Killam Trusts.

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