Stuart Trenholm's lab studies how neural connectivity enables us to see objects around us. His work could discover new ways to improve the vision of people who have lost their sight by understanding how the specific wiring of neuronal circuits in the visual system leads to complex visually responsive neurons and ultimately leads to perception. The lab studies visual circuits in healthy, vision-impaired and vision-rehabilitated animals. The lab merges multiple disciplines, including physiology, animal behaviour, virology, genetics, disease models and optogenetics. Techniques in the lab include monitoring brain activity at cellular resolution using in vivo 2-photon calcium imaging, utilizing virus-mediated neuronal circuit tracing strategies, and implementing optogenetic vision restoration strategies.
Selected publications
Hillier D, Fiscella M, Drinnenberg A,听Trenholm S, Rompani SB, Raics Z, Katona G, Juttner J, Hierlemann A, Rozsa B, Roska B (2017) Causal evidence for retina-dependent and 鈥搃ndependent visual motion computation in mouse cortex.听Nature Neuroscience. 20: 960-68.
Wertz A*,听Trenholm S*, Yonehara K, Hillier D, Raics Z, Leinwieber M, Szalay G, Keller G, Rozsa B, Conzellman KK, Roska B (2015) Single-cell-initiated monosynaptic tracing reveals layer-specific cortical network modules.听Science.听349:70-4.听*indicates equal contribution.听
Trenholm S听& Awatramani GB (2015) Origins of spontaneous activity in the degenerating retina.Frontiers in Cellular Neuroscience. 9:277.听doi: 10.3389.听 听听
Trenholm S*, McLaughlin AJ*, Schwab DJ, Turner MH, Smith RG, Rieke F, Awatramani GB (2014)听Non-linear dendritic integration of electrical and chemical synaptic inputs drives fine-scale correlations.Nature Neuroscience. 17:1759-66. *indicates equal contribution.
Trenholm S, Schwab DJ, Balasubramanian VB, Awatramani GB (2013) Lag normalization in an electrically-coupled neural network.听Nature Neuroscience. 16:154-6.
Trenholm S, Johnson K, Li X, Smith RG, Awatramani GB (2011)听Parallel mechanisms encode direction in the retina.听Neuron. 71:683-94.听 听
