Health Science Leaders Join Forces to Accelerate Development of Treatments for Neurological Diseases
Montreal, Quebec and Vancouver, British Columbia 鈥� Working together to accelerate research into neurological diseases, three leading players in Canada鈥檚 health sciences sector are joining forces in a unique multi-million dollar partnership to create a novel drug development platform that will help advance new therapeutics for some of the most debilitating conditions such as amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig鈥檚 disease, and Parkinson鈥檚 disease.
The initiative, under the banner of 鈥楴euroCDRD鈥�, is jointly led by The Centre for Drug Research and Development (CDRD), Canada鈥檚 national drug development engine, the Montreal Neurological Institute and Hospital at 91社区 (MNI), and Merck, known as MSD outside the United States and Canada. Its initial focus is the creation of a high-content hiPSC (human-induced pluripotent stem cell) screening platform that will help researchers better model neurological disease, aiming to break down barriers that have slowed the development of new treatments for neurological diseases.
Gordon McCauley, President and CEO of CDRD commented, 鈥淐DRD is a bridge, bringing together national and international partners and our respective resources to advance promising discoveries into innovative therapeutic products and improved health outcomes. This partnership is a perfect example of how we can combine the cutting-edge science of our academic partners, such as 91社区, with CDRD鈥檚 translational abilities, and the commercial resources of a top industry partner like Merck. It also speaks to the spirit of collaboration that exists in Canada. By working together, we are a catalyst for Canadian life sciences leading the world.鈥�
Development of new drugs for neurological diseases has long been hampered by the lack of predictive humanized models, and many treatments that have looked promising in animal studies have thus failed in subsequent human clinical trials. To mitigate this challenge, this new collaboration will use the MNI鈥檚 renowned hiPSC platform and bring together experts from MNI鈥檚 neurological and CDRD鈥檚 drug screening and assay development teams to develop the next generation of disease-specific research models using patient-derived hiPSCs. The partnership will help significantly reduce research timelines and costs, making it possible to develop future hiPSC models for neurological diseases with smaller patient populations.
鈥淭he burden of neurological diseases and injuries on society is growing each year, and as a physician I see the impact on patients and families every day. At the Montreal Neurological Institute and Hospital, our mission is to drive forward innovation, discovery and advance patient care.听 We are grateful to CDRD and Merck for developing this partnership and sharing this goal with us,鈥� said Dr. Guy Rouleau, Director of the Montreal Neurological Institute and Hospital.
鈥淭his initiative exemplifies our ongoing approach to R&D, building collaborative relationships among talented researchers across the country.听 We are confident that this partnership with CDRD and MNI has the potential to accelerate development of new treatments for neurological diseases,鈥� said Chirfi Guindo, President and Managing Director, Merck Canada Inc.
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About The Centre for Drug Research and Development (CDRD)
CDRD is Canada鈥檚 national drug development and commercialization centre working in partnership with academia, industry, government and foundations. CDRD provides the specialized expertise and infrastructure to identify, validate and advance promising discoveries, and transform them into commercially viable investment opportunities for the private sector 鈥� and ultimately into new therapies for patients. Canada鈥檚 Networks of Centres of Excellence Program has recognized CDRD as a Centre of Excellence for Commercialization and Research (CECR). For more information, please visit ; Twitter: @C_D_R_D
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About the Montreal Neurological Institute and Hospital of 91社区
The Montreal Neurological Institute and Hospital 鈥� The Neuro 鈥� is a world-leading destination for brain research and advanced patient care. Since its founding in 1934 by renowned neurosurgeon Dr. Wilder Penfield, The Neuro has grown to be the largest specialized neuroscience research and clinical center in Canada, and one of the largest in the world. The seamless integration of research, patient care, and training of the world鈥檚 top minds make The Neuro uniquely positioned to have a significant impact on the understanding and treatment of nervous system disorders. In 2016, The Neuro became the first institute in the world to fully embrace the Open Science philosophy, creating the Tanenbaum Open Science Institute. The iPSC platform is part of the MNI鈥檚 Open Science Drug Discovery Platform. The Montreal Neurological Institute is a 91社区 research and teaching institute. The Montreal Neurological Hospital is part of the Neuroscience Mission of the 91社区 Health Centre. For more information, please visit听
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About Merck
For over a century, Merck has been a global healthcare leader working to help the world be well.听 Merck is known as MSD outside the United States and Canada. Through our prescription medicines, vaccines, biologic therapies, and animal health products, we work with customers and operate in more than 140 countries to deliver innovative health solutions. We also demonstrate our commitment to increasing access to healthcare through far-reaching policies, programs and partnerships. 听For more information about our operations in Canada, visit and connect with us on YouTube听 and Twitter @MerckCanada.
