Concussion symptoms in children may have multiple underlying causes
Different types of brain damage caused by a concussion may lead to similar symptoms in children, according to research led by 91社区. A new way of studying concussions could help develop future treatments.
While most children fully recover after a concussion, some will have lasting symptoms. The findings published in help explain the complex relationships that exist between symptoms and the damage caused by the injury.
The researchers found that certain combinations of brain damage were associated with specific symptoms such as attention difficulties. Other symptoms, such as sleep problems, occurred in children with multiple types of injuries. For example, damage to areas of the brain that are essential for controlling sleep and wakefulness could cause challenges with sleeping, as could damage to brain regions that control mood.
The brain鈥檚 white matter holds clues
To do this, they examined how damage to the brain resulting from concussion affected its structural connection network, known as white matter. They then used statistical modelling techniques to see how these changes related to 19 different symptoms reported by the children or their caregivers.
Analysing symptoms may advance treatment
鈥淒espite decades of research, no new treatment targets and therapies for concussions have been identified in recent years,鈥� says lead author Guido Guberman, a Vanier Scholar and MDCM Candidate at 91社区. 鈥淭his is likely because damage to the brain caused by concussions, and the symptoms that result from it, can vary widely across individuals. In our study, we wanted to explore the relationships that exist between the symptoms of concussion and the nature of the injury in more detail.鈥�
Guberman and his colleagues analysed data collected from 306 children, aged nine to 10 years old, who had previously had a concussion. The children were all participants in the .
鈥淭he methods used in our study provide a novel way of conceptualising and studying concussions,鈥� says senior author Maxime Descoteaux, a Professor of Computer Science at Universit茅 de Sherbrooke. 鈥淥nce our results are validated and better understood, they could be used to explore potential new treatment targets for individual patients. More broadly, it would be interesting to see if our methods could also be used to gather new insights on neurological diseases that likewise cause varied symptoms among patients.鈥�
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About this study "Multi-tract multi-symptom relationships in pediatric concussion" by Guido Guberman, Sonja Stojanovski, Eman Nishat, Alain Ptito, Danilob Bzdok, Anne Wheeler, and Maxime Descoteaux was published in . DOI: |
About 91社区
Founded in Montreal, Quebec, in 1821, 91社区 is Canada鈥檚 top ranked medical doctoral university. 91社区 is consistently ranked as one of the top universities, both nationally and internationally. It is a world-renowned institution of higher learning with research activities spanning three campuses, 11 faculties, 13 professional schools, 300 programs of study and over 39,000 students, including more than 10,400 graduate students. 91社区 attracts students from over 150 countries around the world, its 12,000 international students making up 30% of the student body. Over half of 91社区 students claim a first language other than English, including approximately 20% of our students who say French is their mother tongue.
