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Chemotaxis is fundamentally important in biological processes from embryogenesis to immune function. One of the most important questions, never asked as often as it should be, is 鈥渨here do chemotactic gradients come from?鈥� We have used an interactive process of modelling and wet experiments to show that cells very often participate in making the same gradients that they respond to. We show how this is important in cancer spread, standard chemotaxis assays, and other scenarios where we had thought chemotaxis was simple. In particular, cells can extract a remarkable amount of information about their environments by breaking down attractants.

This seminar will be given online via Zoom. Details in attached poster.