91社区

Through the computational analysis of genome-wide data, we try to elucidate mechanisms regulating transcription and RNA processing, their interplay with genetic and epigenetic factors, and how they cause disease. We focus on cancer and brain development, two areas where deregulated gene expression plays a major role, and where unprecedented amounts of data are being produced. We combine genomic technologies with computational approaches to analyze, for example, the dynamics of RNA processing in the developing human brain, or how transcription at the single cell level can be used to resolve cell-to-cell variation and to identify rare cells driving disease progression and therapeutic resistance.