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I would widely define my research interest as bone-centered physiology. I am interested in understanding how mechanical, biochemical, and cellular microenvironment shapes the function of bone cells; and how the function of bone cells in turn alters micro- and macro-environment of the organism. We use live cell imaging, cell and molecular biology as well as in vivo approaches to study cell-cell and cell-matrix interactions in the bone microenvironment, the role of mechanical forces in regulating bone cells, and the consequences of altered bone resorption for the whole body physiology. In addition, I aim to develop computational support for our projects, including quantitative literature reviews, mathematical models to help in understanding the complex interactions we study, and computational tools for data analysis.