In the few short years since its launch, the has brought together a wide cross-section of 91社区 researchers and, as a result, brought the university into the national conversation on stem cell research and regenerative medicine.
The MRM mission is to support both fundamental and clinical stem cell and regenerative medicine programs and to strengthen these efforts across the 91社区 community and beyond. Terry H茅bert, a professor in the Department of Pharmacology and Therapeutics at 91社区, is the Director of the MRM Network. 鈥淥ur work spans the entire gamut of regenerative medicine at 91社区 bringing together basic scientists, clinicians, engineers, lawyers and ethicists to advance scientific knowledge and applications, and translate new discoveries into clinical practice,鈥� he says.
The network currently comprises more than 130 principal investigators and 250 active members (trainees, staff) from 25 academic departments, five faculties and six research institutes. Their expertise includes work in embryonic, induced pluripotent and adult stem cells, developmental biology and organoids, disease models, cell-based and pharmaceutical therapeutics, tissue bioengineering, and the ethical implications related to regenerative medicine.
Highlighting 91社区鈥檚 expertise
Prof. H茅bert, who is also the Assistant Dean for Biomedical Science Education in the Faculty of Medicine and Health Sciences, explains that several notable achievements within the MRM in the past few years are solidifying 91社区鈥檚 place in the regenerative medicine landscape in Canada. 鈥淲e are becoming known for a particular expertise in building cell therapies for many different diseases,鈥� he says. For example, Corinne Hoesli, PhD, from the Department of Chemical Engineering, runs the Stem Cell Bioprocessing Lab where engineers devise and optimize methods to bring cell-based therapies to the clinical setting for treating diabetes, cardiovascular disease, and cancer.
Building cell therapies is a process where researchers can turn a patient鈥檚 cells into stem cells, and then make the stem cells into any other cell type in that patient鈥檚 body. 鈥淭his allows us to model disease, test therapies, and even look down the road to putting cells back into patients to replenish organ damage, for example,鈥� explains Prof. H茅bert.
The capacity to model disease and transfer cells to patients is one of the MRM鈥檚 unique successes. 鈥淲e鈥檙e very interested in building the pipeline that goes from basic science all the way to clinical translation, that is, from developing new therapies to furthering their impact on patients,鈥� says Prof. H茅bert.
The MRM network is also moving forward with building 3D models of tissues, and researchers have created models of a kidney, heart and brain which mimic the cellular contact and three-dimensional organization of an organ, but on a smaller scale. 鈥淲e can actually study organ-like behaviour in a dish, so it鈥檚 a really powerful way to model disease and understand how organs function under normal conditions,鈥� says Prof. H茅bert.
Bringing the network together
Marine Christin, PhD, is the MRM project manager who, from her office in the Goodman Cancer Institute, acts as the glue for the network. When she started in 2019, her first major project was developing the database that now provides MRM members and prospective members with the information to move projects forward.
鈥淩egenerative medicine is a big umbrella, and our database shows us who is working on what, and where they鈥檙e located,鈥� says Christin. 鈥淢embers can ask me specifically if we know someone working in a particular field or on a particular type of cell, and I can help connect them.鈥� The database is also proving beneficial to students who are looking for training opportunities.
Christin has also been active in MRM efforts to build ties with the provincial network Th茅Cell and the national Stem Cell Network, to help expand the MRM footprint and increase awareness of 91社区鈥檚 activities. Christin continues to build the database by approaching every new faculty member working in any area of regenerative medicine and inviting them to join the network.
Training and involving the next generation
The network is making important efforts to involve students in their own futures, including in the development of new graduate programs.
Molly Shen, a Masters student in the Department of Biomedical Engineering, currently sits on the MRM Executive Committee, and is chair of the MRM Trainee Committee, which supports and represents trainees. 鈥淭he committee is representative of the network鈥檚 diversity,鈥� says Shen, 鈥渁nd we鈥檙e providing trainees with opportunities to meet and exchange ideas.鈥� The committee held its first Meet and Greet networking event this fall, is developing a Graduate Mentorship program and Career Development networking series with industry experts, and has plans for an online platform to facilitate communication among trainees.
Support for success
The MRM is committed to promoting the impact of its clinical and research network, part of which involves providing seed funding for research projects using 91社区 core facilities. Alex Gregorieff, PhD, Assistant Professor, Department of Pathology at 91社区 and the RI-MUHC, is one of several recent grant recipients. He is developing a patient-derived enteroid biobank to study the role of intestinal stem cells in inflammatory bowel disease (IBD), which over the long term will provide researchers at 91社区 and elsewhere a unique resource to study certain factors in this difficult to treat disease.
Prof. H茅bert feels the future of regenerative medicine at 91社区 can only get stronger. He looks to his own lab as an example of what is happening across the network. 鈥淥ur work has evolved to a point where we are asking questions that are relevant to disease and relevant in a personalized way for individual patients, so we can actually imagine how it will impact them at some point,鈥� he says. 鈥淚t鈥檚 a powerful motivation as a non-clinician to see how our work will help people in the future.鈥�
Disclaimer: This article was originally published in .
