Mariane Bertagnolli
Assistant Professor
B.Sc. in Physiotherapy, Universidade Federal de Santa Maria, Brazil听
M.Sc. in Physiology, Universidade Federal do Rio Grande do Sul, Brazil
Ph.D. in Physiology, Universidade Federal do Rio Grande do Sul, Brazil
Postdoctoral fellowship in Biomedical Sciences, CHU Sainte-Justine, Universit茅 de听Montr茅al, Canada
Postdoctoral fellowship in Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, United Kingdom
PHTH 554 Cardiorespiratory Rehabilitation
PHTH 564听Integrated Cardiorespiratory Rehabilitation
Prof. Bertagnolli鈥檚 current research program focuses on elucidating mechanisms that can interrupt the formation of new blood vessels in the mother, placenta and growing fetus in pregnancies that are severely affected by hypertensive disorders such as pre-eclampsia. Her laboratory uses a translational approach with murine models and clinical samples to investigate the mechanisms and therapies, including exercise rehabilitation aimed at improving听vascularization and, ultimately, preventing disease in women and their children. Research interests include assessing endothelial and microvascular changes in hypertensive pregnancies and investigating the effects of cardiac and obstetric rehabilitation interventions for听these patients and their children.
Hypertensive disorders of pregnancy and fetal programming of heart disease
Mechanisms of angiogenesis
Exercise physiology
Socioeconomic determinants of women's health
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Burchert H, Lapidaire W, Williamson W, McCourt A, Dockerill C, Woodward W, Tan CM,听Bertagnolli M, Mohamed A, Alsharqi M, Hanssen H, Huckstep OJ, Leeson P, Lewandowski AJ (2022). Aerobic Exercise Training Response in Preterm-Born Young Adults with Elevated Blood Pressure and Stage 1 Hypertension: A Randomised Controlled Trial.听American Journal of Respiratory and Critical Care Medicine. 2022 Dec 2. doi: 10.1164/rccm.202205-0858OC.听
Al-Huda F, Shapiro GD, Davenport MH,听Bertagnolli M, Dayan N (2022).听Association between Cardiorespiratory Fitness and Hypertensive Disorders of Pregnancy: A Systematic Review and Meta-Analysis.听Journal of Clinical Medicine. 2022 Jul 27;11(15):4364. doi: 10.3390/jcm11154364.
Williamson W, Lewandowski AJ, Huckstep OJ, Lapidaire W, Ooms A, Tan C, Mohamed A, Alsharqi M,听Bertagnolli M, Woodward W, Dockerill C, McCourt A, Kenworthy Y, Burchert H, Doherty A, Newton J, Hanssen H, Cruickshank JK, McManus R, Holmes J, Ji C, Love S, Frangou E, Everett C, Hillsdon M, Dawes H, Foster C, Leeson P (2022). Effect of moderate to high intensity aerobic exercise on blood pressure in young adults: The TEPHRA open, two-arm, parallel superiority randomized clinical trial. EClinicalMedicine. 48:101445. doi: 10.1016/j.eclinm.2022.101445.
Bertagnolli M, Dartora DR, Lamata P, Zacur E, Mai-Vo TA, He Y, Beauchamp L, Lewandowski AJ, Cloutier A, Sutherland MR, Santos RAS, Nuyt AM (2022).听Reshaping the Preterm Heart: Shifting Cardiac Renin-Angiotensin System Towards Cardioprotection in Rats Exposed to Neonatal High-Oxygen Stress. Hypertension. 79(8):1789-1803. doi: 10.1161/HYPERTENSIONAHA.122.19115.
Lewandowski AJ, Raman B,听Bertagnolli M, Mohamed A, Williamson W, Pelado JL, McCance A, Lapidaire W, Neubauer S, Leeson P (2021).听Association of Preterm Birth With Myocardial Fibrosis and Diastolic Dysfunction in Young Adulthood. Journal of the American College of Cardiology. 78(7):683-692.听doi: 10.1016/j.jacc.2021.05.053.
Azinheira Nobrega Cruz N, Stoll D, Casarini DE,听Bertagnolli M (2021).听Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility. Clinical Science. 135(15):1805-1824.听doi: 10.1042/CS20210284.
Lewandowski AJ, Raman B,听Bertagnolli M, Mohamed A, Williamson W, Pelado JL, McCance A, Lapidaire W, Neubauer S, Leeson P (2021).听Association of Preterm Birth With Myocardial Fibrosis and Diastolic Dysfunction in Young Adulthood. Journal of the American College of Cardiology (JACC). 78(7):683-692. doi: 10.1016/j.jacc.2021.05.053.
Jama HA, Muralitharan RR, Xu C, O'Donnell JA,听Bertagnolli M, Broughton BRS, Head GA, Marques FZ (2021). Rodent models of hypertension.听British Journal of Pharmacology.听doi: 10.1111/bph.15650.听
Tan CMJ, Lewandowski AJ, Williamson W, Huckstep OJ, Yu GZ, Fischer R, Simon JN, Alsharqi M, Mohamed A, Leeson P,听Bertagnolli M听(2021).听Proteomic signature of dysfunctional circulating endothelial colony-forming cells of young adults.听Journal of the American Heart Association. e021119. doi: 10.1161/JAHA.121.021119.
Benizri N, Marc C, Achille A, Raguema N, Pepin 脡, Lavoie JL,听Bertagnolli M (2021).听Ultrasound imaging of remodeling in fetal mouse heart and the programming of cardiomyopathy in offspring of superimposed preeclampsia.听Hypertension. 77(5):e47-e49. doi: 10.1161/HYPERTENSIONAHA.121.16959.
Huckstep OJ, Burchert H, Williamson W, Telles F, Tan CMJ, Bertagnolli M, Arnold L, Mohamed A, McCormick K, Hanssen H, Leeson P, Lewandowski AJ (2020). Impaired myocardial reserve underlies reduced exercise capacity and heart rate recovery in preterm-born young adults. European Heart Journal Cardiovascular Imaging. jeaa060. doi: 10.1093/ehjci/jeaa060.
Raguema N, Moustadraf S, Bertagnolli M (2020). Immune and Apoptosis Mechanisms Regulating Placental Development and Vascularization in Preeclampsia. Frontiers Physiology. 11;11:98. doi: 10.3389/fphys.2020.00098.
Williamson W, Huckstep O, Frangou E, Mohamed A, Tan C, Alsharqi M, Bertagnolli M, Lapidaire W, Newton J, Hanssen H, McManus R, Dawes H, Foster C, Lewandowski A, Leeson P (2018). Trial of Exercise to Prevent HypeRtension in young Adults (TEPHRA) a randomized controlled trial: Study Protocol. BMC Cardiovascular Disorders.18(1):208.
Huckstep OJ, Williamson W, Telles F, Burchert H, Bertagnolli M, Herdman C, Arnold L, Smillie R, Mohamed A, Boardman H, McCormick K, Leeson P, Lewandowski AJ (2018). Physiological stress elicits impaired left ventricular function in preterm-born adults. Journal of the American College of Cardiology (JACC). 71(12):1347-1356.
Bertagnolli M, Xie L, Paquette K, He Y, Cloutier A, Delfrate J, Curnier D, Lukaszewski MA, Sutherland M, Bigras JL, Thebaud B, Rivard, A, Luu TM, Nuyt AM (2018). Endothelial colony- forming cells in preterm born young adults: A novel link between neonatal complications and adult risks to cardiovascular diseases. Journal of the American Heart Association.听7(14). pii: e009720.
Bertagnolli M, Nuyt AM, Thebaud B, Luu TM (2017). Endothelial progenitor cells as prognostic markers of preterm birth-associated complications. Stem Cells Translational Medicine. 6(1):7-13.
Bertagnolli M, Luu TM, Lewandowski AJ, Leeson P, Nuyt AM (2016). Preterm birth and hypertension: Is there a link? Current Hypertension Reports. 18(4):28
Bertagnolli M, Dios A, B茅land-Bonenfant S, Gascon G, Sutherland M, Lukaszewski MA, Cloutier A, Paradis P, Schiffrin EL, Nuyt AM (2016). Activation of the cardiac renin-angiotensin system in high oxygen-exposed newborn rats: Angiotensin receptor blockade prevents the developmental programming of cardiac dysfunction. Hypertension. 67(4):774-82.
Bertagnolli M, Huyard F, Cloutier A, Anstey Z, Huot-Marchand J脡, Fallaha C, Paradis P, Schiffrin EL, Deblois D, Nuyt AM (2014). Transient neonatal high oxygen exposure leads to early adult cardiac dysfunction, remodeling and activation of the renin angiotensin system. Hypertension. 63(1):143-50.
Bertagnolli M, Casali KR, De Sousa FB, Rigatto K, Becker L, Santos SH, Dias LD, Pinto G, Dartora DR, Schaan BD, Milan RD, Irigoyen MC, Santos RA (2014). An orally active angiotensin-(1-7) inclusion compound and exercise training produce similar cardiovascular effects in spontaneously hypertensive rats. Peptides. 51:65-73.
Bertagnolli M, Schenkel PC, Campos C, Mostarda C, Casarini DE, Bell贸-Klein A, Irigoyen MC, Rigatto K (2008). Exercise training reduces sympathetic modulation on cardiovascular system and cardiac oxidative stress in spontaneously hypertensive rats. American Journal of Hypertension. 21(11):1188-93.
Bertagnolli M, Campos C, Schenkel PC, de Oliveira VL, De Angelis K, Bell贸-Klein A, Rigatto K, Irigoyen MC (2006). Baroreflex sensitivity improvement is associated with decreased oxidative stress in trained spontaneously hypertensive rats. Journal of Hypertension. 24(12):2437-43.
